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Employee's Directory
Dr. Muhammad Ali, Ph.D.

Department:  Faculty of Sciences, Department of Biochemistry

Position:  Assistant Professor

HEC Approved Supervisor:  YES

Research Intersts:  Molecular Biology, Cell Biology, Recombinant DNA technology, and Genetic Engineering We deal with the transcriptional, translational, and metabolic studies for the treatment of diabetes, breast cancer, and liver injury. We use docking tools to find candidate drugs for the treatment of above stated diseases. We utilized prokaryotic system, cell lines, and mouse models for our research work. Along with metabolic studies, study of signaling pathway is specialty of MMGL (Mammalian Molecular Genetics Lab). For the study of these pathways, we use Western blotting. We also routinely use different software like MOE, NCBI, Ensemble, Primer quest, Mega 6.06, SnapGene, and GraphPad. a) Diabetes (drugs, phytochemicals, signaling pathway, mechanism, and in-vivo studies) b) Liver injury (drugs, phytochemicals, signaling pathway, mechanism, and in-vivo studies) c) Breast cancer (drugs, phytochemicals, signaling pathway, mechanism, and in-vivo studies) d) CRISPR/Cas9-mediated gene editing (knockout, cKO, and transgenic) e) Mouse models of human diseases for in-vivo studies f) Docking by MOE; basic tools of bioinformatics for recombinant DNA technology, primer designing g) Production of recombinant monoclonal antibodies For more detail, please visit our website: http://lifesciencesorg.com

Publications:  

Journal Articles:
  1. Muhammad Ali, Rida Iqbal , Muhammad Safdar , Sehrish Murtaza , Ghulam Mustafa , Muhammad Sajjad , Shazia Anwer Bukhari , Tayyaba Huma, 2021, Antioxidant and antibacterial activities of Artemisia absinthium and Citrus paradisi extracts repress viability of aggressive liver cancer cell line, Molecular Biology reports , 48(12), 7703-7710
  2. Rawaba Arif, Sajjad Ahmad, Ghulam Mustafa, Hafiza Salaha Mahrosh, Muhammad Ali, Muhammad Tahir ul Qamar, Hafiza Rabia Dar, 2021, Molecular docking and simulation studies of antidiabetic agents devised from hypoglycemic polypeptide-P of Momordica charantia, BioMed Research International , 2021, 5561129
  3. Ghulam Mustafa, Rawaba Arif , Shazia Anwer Bukhari , Muhammad Ali , Sumaira Sharif , Asia Atta, 2018, Structural and functional annotation of citrate synthase from Aspergillus niger ANJ-120, PJPS, 31 (2), 709-717
  4. Muhammad Ali, Shazia Anwer Bukhari, Muhammad Ali, and Han-Woong Lee, 2017, Upstream Signalling Regulates Hyperactivation of mTORC1 in Type 2 Diabetes and Hypertriglyceridemia, BMB reports , 50(12), 601?609
  5. Muhammad Ali, Sushil Devkota, Jae-Il Roh, Jaehoon Lee, Han-Woong Lee, 2016, Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1, BBRC, 478 (3), 1198-1204
  6. Sushil Devkota, Hyobin Jeong, Yunmi Kim, Muhammad Ali, Jae-Il Roh, Daehee Hwang, Han-Woong Lee, 2016, Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases, Autophagy, 12 (11), 2038-2053
  7. Young Hoon Sung, Muhammad Ali, Han-Woong Lee, 2014, Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models, Yonsei medical journal, 55(1), 1-8
  8. Muhammad Ali, Euijin Hwang, Il-Hwan Cho, Myeong Hee Moon, 2012, Characterization of sodium hyaluronate blends using frit inlet asymmetrical flow field-flow fractionation and multiangle light scattering, Analytical and bioanalytical chemistry, 402(3), 1269-1276
  9. Farooq Anwar, Muhammad Ali, Abdullah Ijaz Hussain, Muhammad Shahid, 2009, Antioxidant and antimicrobial activities of essential oil and extracts of fennel seeds from Pakistan, Flavour and fragrance journal, 24(4), 170-176
Status:

TTS

Phone:

+92-41-9200161-70 Ext: 3358

Fax:

+92-41-9200764

Mobile:

03336606630

dr.muhammadali@uaf.edu.pk

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