Department:  Faculty of Veterinary Science, Institute of Microbiology

Position:  Assistant Professor

HEC Approved Supervisor:  YES

Research Intersts:  The research interests of my career are focused on understanding the molecular and immunological basis of public health infectious diseases at human-animal interface such as Salmonella, Campylobacter, nosocomial infections, HBV, HCV and developing different animal models of hepatitis. My veterinary background and the study of cytokines during hepatitis further motivated me to investigate the innate and adaptive immune responses during various infectious diseases. Stimulation of innate immune receptors by specific bacterial or viral ligands and shift towards adaptive immune compartment by cytokines provide interesting tool to manipulate host immune system for better protection against infections. I have experience to study the veterinary associated infectious diseases during my masters in Pakistan and cytokine immunology during my masters/Ph.D research in France. This combination of both competencies will help me to use these immunological molecules in the enhancement of vaccine responses against prevalent infectious diseases of public health. I have extensive experience in characterization of cellular and molecular immune responses during hepatitis in murine animal models and in human that will help to use this immunology based knowledge for the therapeutic and diagnostic purposes. My future goals will be to study the immuno-pathogenesis of emerging infectious diseases and to develop preventive strategies against prevalent Public Health/One Health diseases.

Publications:  

1. Roston, O. , M. I. Arshad, C. Piquet-Pellorce, F. Robert-Gangneux, J. P. Gangneux, and M. Samson, 2015, Crucial and diverse role of IL-33/ST2 axis in infectious diseases, Infection and Immunity, 83(5), 1738-48
2. Arshad MI, Filliol A, Genet V, Lucas-Clerc C, Girard J.P, Piquet-Pellorce C and Samson M. , 2014, Deficiency of IL-33 sensitizes to severe liver injury induced by ConA but not by CCl4 in mice., Journal of Hepatology, 60, S67-S214
3. Arshad MI, Patrat-Delon S, Piquet-Pellorce C, L, 2013, Pathogenic Mouse Hepatitis Virus or Poly(I:C) Induce IL-33 in Hepatocytes in Murine Models of Hepatitis. , PLoS One, 8(9), e74278
4. Arshad MI, Piquet-Pellorce C, Samson M. , 2012, IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology. , Liver International, 32(8), 1200-10
5. Hussain I, Mahmood MS, Arshad MI, Akhtar M, Mahmood F, Rafique A. , 2012, Immune system dysfunction in broiler chickens experimentally inoculated with fowl adenovirus serotype-4 associated with inclusion body hepatitis hydropericardium syndrome. , Turkish Journal of Veterinary and Animal Sciences, 36(3), 223-230
6. Arshad MI, Piquet-Pellorce C, L, 2012, TRAIL, but not FasL and TNFa, regulates IL-33 expression in murine hepatocytes during acute hepatitis., Hepatology, 56(6), 2353-62
7. Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Van, 2012, TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. , Cell Death and Differentiation, 19(12), 2003-2014
8. Arshad MI, Patrat-Delon S, L, 2012, NKT cells and TRAIL induce hepatocyte IL-33 in murine acute hepatitis. , Cytokine, 59(3), 549
9. Le Goffic R, Arshad MI, Rauch M, L, 2011, Influenza virus infection induces IL-33 in murine lungs. , American Journal of Respiratory Cell and Molecular Biology,, 45, 1125–1132
10. Arshad MI, Rauch M, L, 2011, NKT cells are required to induce high IL-33 expression in hepatocytes during ConA-induced acute hepatitis. , European Journal of Immunology, 41(8), 2341-8
11. Mahmood MS, Hussain I, Arshad MI, Ali S, Aktar M, Khan A, Mahmood F., 2009, Seasonal Prevalence of Campylobacter Species in Milk and Milk Products in Pakistan. , Pakistan J. Zool. , 9, 227-231
12. Hussain I, Arshad MI, Mahmood MS, Akhtar M, Ali S, Khan A and Mahmood F. , 2009, Clinico-epidemiological, microbiological and antibiogram studies of Corynebacterium bovis associated with mastitis in buffaloes (Bubalus bubalis). , Pakistan J Zool., 9, 818-823
13. Hussain I, Arshad MI, Mahmood MS, Akhtar M. , 2008, Seroprevalence of Brucellosis in Human, Cattle, and Buffalo Populations in Pakistan. , Turkish Journal of Veterinary and Animal Sciences, 32 (4), 315-318

TTS

+92-41- 9200161-170: Ext 3113

+92-41-9200187

+92-3445007759

drimranarshad@yahoo.com