Department:  Faculty of Veterinary Science, Department of Pharmacy

Position:  Assistant Professor

HEC Approved Supervisor:  YES

Research Intersts:  Metabolic and Endocrine disorders: • Recognition of molecular pathogenesis. • Assessment of targeted therapy for identified molecular pathogenic factors involved. • Evaluation of various therapeutic aspects of identified/new drug entities including phytonutrient molecules through in silico, in vitro and in vivo methods. • Safety profile of new therapeutic drugs used in targeted treatment. Assessment and interventions for environmental pollutant-induced.

Publications:  

1. , 2019, Taxifolin prevents postprandial hyperglycemia by regulating the activity of a-amylase: evidences from an in vivo and in silico studies. , J Cell Biochem, 120(1), 425-38.
2. , 2018, Investigations of phytochemical constituents and their pharmacological properties isolated from genus utrica: Critical review and analysis. , Crit Rev Eukaryot Gene Expr., 28(1):, 25-66.
3. , 2018, An insight into the emerging role of cyclin-dependent kinase inhibitors as potential therapeutic agents for the treatment of advanced cancers. , Biomed Pharmacother. , 107, 1326-41.
4. Rehman, K. , and M. Akash, 2017, Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: how are they interlinked? (IF= 3.446), J Cell Biochem, 118, 3577-3585
5. Akash, M. , K. Rehman, and A. Liaqat, 2017, Tumor necrosis factor-alpha: Role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus. (IF= 3.446) , J Cell Biochem. , DOI:10.100,
6. Rehman, K. , F. Fatima, I. Waheed, and M. Akash, 2017, Prevalence of exposure of heavy metals and their impact on health consequences. (IF= 3.446), J Cell Biochem, DOI: 10.10,
7. Ibrahim, M. , K. Rehman, I. Hussain, T. Farooq, B. Ali, I. Majeed, and M. Akash, 2017, Ethnopharmacological investigations of phytochemical constituents isolated from genus Cuscuta. (IF= 1.66), Crit Rev Eukaryot Gene Expr, DOI: 10.16,
8. Rehman, K. , M. Akash, A. Liaqat, S. kamal, M. I. Qadir , and A. Rasul , 2017, Role of interleukin-6 in development of insulin resistance and type 2 diabetes mellitus. (IF= 1.66), Crit Rev Eukaryot Gene Expr, 27, 229-236
9. Farooq, T. , A. Hameed , K. Rehman, M. Ibrahim, M. Ahmed, T. Gulzar, and M. Akash, 2017, Emerging trends in non-interferon-based genotype specific antiviral agents: pharmaceutical perspectives, Crit Rev Eukaryot Gene Expr, (in press), (in press)
10. Akash, M. , K. Rehman, A. Parveen, and M. Ibrahim, 2016, Antibody-drug conjugates as drug carrier systems for bioactive agents. (IF= 3.568), Int J Polym Mat Polym Biomat, 65, 1-10
11. Akash, M. , K. Rehman, and S. Chen, 2016, Polymeric-based particulate systems for delivery of therapeutic proteins. (IF= 1.202), Pharm Dev Technol, 21, 367-378
12. Rehman, K. , M. Akash, B. Akhtar, M. Tariq, A. Mahmood, and M. Ibrahim, 2016, Delivery of therapeutic proteins: challenges and strategies. (IF= 3.021), Curr Drug Targets, 17, 1172-1188
13. Rehman, K. , and M. Akash, 2016, Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? (IF= 2.935), J Biomed Sci, 23, 87
14. Parveen, A. , M. Akash, K. Rehman, and W. W. Kyunn , 2016, Dual Role of p21 in the Progression of Cancer and Its Treatment (IF= 1.571), Crit Rev Eukaryot Gene Expr, 26, 49-62
15. Rehman, K. , and M. Akash, 2016, Nutrition and Diabetes Mellitus: How are They Interlinked? (IF= 1.66)., Crit Rev Eukaryot Gene Expr, 26, 317-332
16. Farooq , T. , A. Hameed , K. Rehman, M. Ibrahim, M. I. Qadir , and M. Akash, 2016, Anti-retroviral agents: looking for best possible chemotherapeutic options to conquer HIV (IF= 1.66), Crit Rev Eukaryot Gene Expr, 26, 363-381
17. Zahra, N. , K. Rehman, R. Aqeel, A. Parveen, and M. Akash, 2016, Assessment of urinary tract infection and their resistance to antibiotics in diabetic and non-diabetic patients. , Bangabandhu Sheikh Mujib Med Univ J, 9, 151-155
18. Akash, M. , and K. Rehman, 2015, Recent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives. (IF= 7.705), J Control Release, 209, 120-138
19. Akash, M. , and K. Rehman, 2015, Natural and synthetic polymers as drug carriers for delivery of therapeutic proteins. (IF= 6.156), Polym Rev, 55, 371-406
20. Akash, M. , K. Rehman, M. Tariq, and S. Chen, 2015, Zingiber officinale and type 2 diabetes mellitus: Evidences from experimental studies (IF= 1.571) , Crit Rev Eukaryot Gene Expr, 25, 91-112
21. Wang, Q. Q. , Y. F. Lan, K. Rehman, Y. H. Jiang, Y. Maimaitiyiming, D. Y. Zhu, and H. Hua Naranmandura, 2015, Effect of Arsenic Compounds on the in Vitro Differentiation of Mouse Embryonic Stem Cells into Cardiomyocytes. (IF = 3.529) , Chem Res Toxicol, 28, 351-353
22. Akash, M. , K. Rehman, M. Tariq, and S. Chen, 2015, Development of therapeutic proteins: Advances and challenges (IF= 1.343), Turk J Biol, 39, 343-358
23. Hussain, L. , M. Akash, M. Tahir, and K. Rehman, 2015, Hepatoprotective effects of Sapium sebiferum in paracetamol-induced liver injury., Bangladesh J Pharmacol, 10, 393-398
24. Hussain, L. , M. Akash, N. U. Ain, K. Rehman, and M. Ibrahim, 2015, Analgesic, anti-inflammatory and anti-pyretic activities of Tinospora cordifolia. (IF= 1.095), Adv Clin Exp Med, 24, 957-964
25. Hussain, L. , M. Akash, S. Naseem, K. Rehman, and K. Z. Ahmed, 2015, Anti-Ulcerogenic Effects of Salmalia Malabarica in Gastric Ulceration – Pilot Study (IF 1.095), Adv Clin Exp Med, 24, 595-605
26. Rehman, K. , Y. J. Fu, Y. F. Zhang, Q. Q. Wang, B. Wu, Y. Wu, X. Y. Zhou, W. H. Sun, . F. Sun, and . Naranmandura, 2014, Trivalent methylated arsenic metabolites induce apoptosis in human myeloid leukemic HL-60 Cells through generation of reactive oxygen species. (IF = 3.585), Metallomics, 6, 1502-1512
27. Akash, M. , K. Rehman, and S. Chen, 2014, Pluronic F127-based thermosensitive gels for delivery of therapeutic proteins and peptides. (IF= 6.156)., Polym Rev, 54, 573-594
28. Akash, M. , K. Rehman, S. Chen,, 2014, Effects of coffee on type 2 diabetes mellitus. (IF= 2.926), Nutrition, 30, 755-763
29. Akash, M. , K. Rehman, and S. Chen, 2014, Spice plant Allium Cepa: Dietary supplement for treatment of type 2 diabetes mellitus. (IF= 2.926)., Nutrition, 30, 1128-1137
30. Lei, Y. , Q. Zhang, L. Fang, M. Akash, K. Rehman, Z. Liu, W. Shi, and S. Chen, 2014, Development and Comparison of two competitive ELISAs for estimation of cotinine in human exposed to environmental tobacco smoke. (IF= 2.506), Drug Test Anal, 6, 1020-1027
31. Akash, M. , K. Rehman, H. Sun, and S. Chen, 2014, Assessment of release kinetics, stability and polymer interaction of PF127-based thermosensitive gel of interleukin-1 receptor antagonist. (IF= 1.202)., Pharm Dev Technol, 19, 278-284
32. Rehman, K. , M. Tariq, M. Akash, Z. Gillani, and M. H. Qazi, 2014, Effect of HA14-1 on apoptosisregulating proteins in HeLa cells. (IF= 2.485)., Chem Biol Drug Des, 83, 317-323
33. Rehman, K. , M. J. Iqbal, . Zahra, and M. Akash, 2014, Liver stem cells: From preface to advancements. (IF= 2.212), Curr Stem Cell Res Ther, 9, 10-21
34. Chen, B. , M. Akash, K. Rehman, H. Sun, and S. Chen, 2014, Expression and bioactivity analysis of staphylococcal enterotoxin G and staphylococcal enterotoxin I. (IF= 1.241), Pharm Biol, 52, 8-13
35. Lei, Y. , W. Liu, M. Akash, K. Rehman, H. Naranmandura, W. Shi, W. Lu, Y. Xu, and S. Chen, 2014, Assessment of urinary concentration of cotinine in Chinese pregnant women exposed to environmental tobacco smoke. (IF= 1.579), Chinese Sci Bull, 59, 1386-1391
36. Hussain, L. , J. Ikram, K. Rehman, M. Tariq, M. Ibrahim, and M. Akash, 2014, Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity. (IF= 1.343), Turk J Biol, 38, 396-402
37. Hussain, L. , M. Akash, M. Tahir, K. Rehman, and K. Z. Ahmed, 2014, Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice. (IF= 1.052), Bangladesh J Pharmacol, 9, 322-327
38. Parveen, A. , M. Akash, K. Rehman, Q. Mahmood, and M. I. Qadir , 2014, Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala. (IF= 0.39), BioImpacts, 4, 43-48
39. Akash, M. , K. Rehman, and S. Chen, 2014, An overview of valuable scientific models for diabetes mellitus. (IF= 3.22)., Curr Diabetes Rev, 9, 286-293
40. Rehman, K. , and H. Naranmandura, 2013, Double-Edged Effects of Arsenic Compounds: Anticancer and Carcinogenic Effects. (IF= 2.976), Curr Drug Metab, 14, 1029-1041
41. Naranmandura, H. , K. Rehman, X. C. Le, and D. J. Thomas, 2013, Formation of Methylated Oxyarsenicals and Thioarsenicals in Wild-Type and Arsenic (+ 3 Oxidation State) Methyltransferase Knockout Mice Exposed to Arsenate. (IF = 3.436), Anal Bioanal Chem, 405, 1885-1891
42. Akash, M. , K. Rehman, and S. Chen, 2013, IL-1Ra and its delivery strategies: Inserting the association in perspective. (IF= 3.952), Pharm Res, 30, 2951-2966
43. Akash, M. , K. Rehman, H. Sun, and S. Chen, 2013, Sustained delivery of IL-1Ra from PF127 gel reduces hyperglycemia in diabetic GK rats. (IF= 3.534)., PLoS One, 8, 55925
44. Akash, M. , K. Rehman, and S. Chen, 2013, Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. (IF= 3.368), J Cell Biochem, 114, 525-531
45. Akash, M. , K. Rehman, H. Sun, and S. Chen, 2013, Interleukin-1 receptor antagonist improves normoglycemia and insulin sensitivity in diabetic GK-rats. (IF= 2.684)., Eur J Pharmacol, 701, 87-95
46. Akash, M. , K. Rehman, and S. Chen, 2013, Goto-kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous Type 2 Diabetes Mellitus. (IF= 3.22)., Curr Diabetes Rev, 9, 387-396
47. Akash, M. , K. Rehman, Z. Gillani, H. Sun, and S. Chen, 2013, Cross-species amino acids sequence comparison and computational docking of human IL-1Ra and Rat IL-1Ra on rat receptor. , J Proteomics Bioinform., 6, 38-42
48. Lu, P. , S. Xu, M. Zhang, . . Wang, Y. F. Zhang, K. Rehman, H. Naranmandura, and . Chen, 2013, Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide. (IF= 3.978)., Metallomics, 5, 871-877
49. Lei, Y. , L. Fang, M. Akash, Z. Liu, W. Shi, and S. Chen, 2013, Estimation of Urinary Concentration of Aflatoxin M1 in Chinese Pregnant Women. (IF= 1.696)., J Food Sci, 78, T1835-T183
50. Rehman, S. , K. Rehman, and M. Akash, 2013, A prospective study of inpatients to determine microbial etiology and therapeutic outcome of antibiotics for community-acquired pneumonia in Pakistan. (IF= 0.39)., Bioimpacts, 3, 91-95
51. Akash, M. , F. Iqbal, M. Raza, K. Rehman, S. Ahmed, Y. Shahzad, S. N. Shah,, 2013, Characterization of ethylcellulose and hydroxypropyl methylcelluse microspheres for controlled release of flurbiprofen. , J Pharm Drug Deliv Res, 2,
52. Bilal, A. , K. Rehman, M. Akash, K. h, M. Ibrahim, and S. S. Hussan, 2013, Development and validation of analytical method for qualitative and quantitative determination of Glibenclamide in different brands of tablet dosage form using UV-visible spectroscopy. (IF= 2.89), J Mol Genet Med, 7, 80
53. Anjum, R. , N. Zahra, K. Rehman, R. Alam, A. Parveen, M. Tariq, M. Akash,, 2013, Comparative analysis of serum lipid profile between normotensive and hypertensive Pakistani pregnant women. , J Mol Genet Med, 7, 64
54. Rehman, K. , and H. Naranmandura, 2012, Arsenic metabolism and thioarsenicals. (IF= 4.099)., Metallomics, 4, 881-892
55. Rehman, k. , Z. Chen, W. W. Wang, Y. w. Wang, A. Sakamoto, Y. F. Zhang, H. Naranmandura, and N. Suzuki, 2012, Mechanisms Underlying the Inhibitory Effects of Arsenic Compounds on Protein Tyrosine Phosphatase (PTP). (IF= 3.705)., Toxicol. Appl. Pharmacol, 263, 273-280
56. Akash, M. , K. Rehman, N. Li, J. Q. Gao, H. Sun, and S. Chen, 2012, Sustained delivery of IL-1Ra from Pluronic F127-based thermosensitive gel prolongs its therapeutic potentials. (IF= 4.742)., Pharm Res, 29, 3475-3485
57. Akash, M. , K. Rehman, Q. Shen, and S. Chen, 2012, Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus. (IF= 3.130)., J Pharm Sci, 101, 1647-1658
58. Naranmandura, H. , S. Xu, S. Koike, L. Q. Pan, B. Chen, Y. w. Wang, K. Rehman, B. Wu, Z. Chen, and N. Suzuki, 2012, The Endoplasmic Reticulum is a Target Organelle for Trivalent Dimethylarsinic Acid (DMAIII)-Induced Cytotoxicity. (IF= 3.975)., Toxicol. Appl. Pharmacol, 260, 241-249
59. Naranmandura, H. , X. Chen, M. Tanaka, W. W. Wang, K. Rehman, S. Xu, Z. Chen, S. Chen, and N. Suzuki, 2012, Release of Apoptotic Cytochrome c From Mitochondria by Dimethylarsinous Acid Occurs Through Interaction With Voltage-Dependent Anion Channel In Vitro. (IF = 4.328)., Toxicol Sci, 128, 137-146
60. Rehman, K. , M. Akash, S. Azhar, S. A. Khan, A. R, W. A, G. Murtaza, and T. A. Sherazi, 2012, A Biochemical and histopathologic study showing protection and treatment of gentamicininduced nephrotoxicity in rabbits using vitamin C. (IF=0.518), Afr J Tradit Complement Altern Med, 9, 360-365
61. Parveen, A. , M. Akash, K. Rehman, M. Tariq, N. Zahra, and T. Iqbal, 2012, Biodisposition kinetics of isoniazid in healthy females, J App Pharm, 4, 676-681
62. Akash, M. , K. Rehman, F. Rasool , A. Sethi, M. A. Abrar, A. Irshad, A. Abid, G. Murtaza,, 2011, Alternate therapy of Type 2 diabetes mellitus (T2DM) with Nigella (Ranunculaceae) (IF=0.897), J Med Plants Res, 5, 6885-6889
63. Abrar, M. A. , T. Abas, G. Murtaza, M. Akash, K. Rehman, and S. H. Shah, 2009, Evaluation of cardiac biomarkers and risk factors to assess myocardial infarction, J Res Sci, 21, 29-37

TTS

+92-41-9200161-70

0333-1705831

kanwal.akash@uaf.edu.pk